IV Vitamin C for Cancer Treatment
Practitioners all over the world use intravenous infusions of ascorbate in doses as high as 60-100 grams for cancer treatment. Due to digestive processes, oral doses of vitamin C can never be as high in the blood as compared to comparable IV doses of vitamin C. Caution: People of Mediterranean descent should be screened for a genetic defect - glucose-6-phosphate dehydrogenase - that may make these high doses of IV vitamin C lethal in them. (breastcancerchoices.org)
For more information refer to:
http://breastcancerchoices.org
Links to research articles on High dose Vitamin C
- Padayatty SJ, Levine M (2000) Reevaluation of ascorbate in cancer treatment: emerging evidence, open minds and serendipity. J Am Coll Nutr 19(4): 423–425.
FIND THIS ARTICLE ONLINE - Padayatty SJ, Sun H, Wang Y, Riordan HD, Hewitt SM, et al. (2004) Vitamin C pharmacokinetics: Implications for oral and intravenous use. Ann Intern Med 140: 533–537.
FIND THIS ARTICLE ONLINE - Chen Q, Espey MG, Krishna MC, Mitchell JB, Corpe CP, et al. (2005) Pharmacologic ascorbic acid concentrations selectively kill cancer cells: action as a pro-drug to deliver hydrogen peroxide to tissues. Proc Natl Acad Sci U S A 102(38): 13604–13609.
FIND THIS ARTICLE ONLINE - Chen Q, Espey MG, Sun AY, Pooput C, Kirk KL, et al. (2008) Pharmacologic doses of ascorbate act as a prooxidant and decrease growth of aggressive tumor xenografts in mice. Proc Natl Acad Sci U S A 105: 11105–11109.
FIND THIS ARTICLE ONLINE - Levine M, Conry-Cantilena C, Wang Y, Welch RW, Washko PW, et al. (1996) Vitamin C pharmacokinetics in healthy volunteers: evidence for a recommended dietary allowance. Proc Natl Acad Sci U S A 93: 3704–3709.
FIND THIS ARTICLE ONLINE - Levine M, Wang Y, Padayatty SJ, Morrow J (2001) A new recommended dietary allowance of vitamin C for healthy young women. Proc Natl Acad Sci U S A 2001; 98(17): 9842–9846.
FIND THIS ARTICLE ONLINE - Hoffer LJ, Levine M, Assouline S, Melnychuk D, Padayatty SJ, et al. (2008) Phase I clinical trial of i.v. ascorbic acid in advanced malignancy. Ann Oncol 19(11): 1969–1974.
FIND THIS ARTICLE ONLINE - Chen Q, Espey MG, Sun AY, Lee JH, Krishna MC, et al. (2007) Ascorbate in pharmacologic concentrations selectively generates ascorbate radical and hydrogen peroxide in extracellular fluid in vivo. Proc Natl Acad Sci U S A 104(21): 8749–8754.
FIND THIS ARTICLE ONLINE - Espey MG, Chen P, Chalmers B, Drisko J, Sun AY, et al. (2011) Pharmacologic ascorbate synergizes with gemcitabine in preclinical models of pancreatic cancer. Free Radic Biol Med 50(11): 1610–1619.
FIND THIS ARTICLE ONLINE - Schulz KF, Altman DG, Moher D, for the CONSORT Group. (2010) CONSORT 2010 Statement: updated guidelines for reporting parallel group randomised trials. Trials 11: 32.
FIND THIS ARTICLE ONLINE - Jackson P, Loughrey CM, Lightbody JH, McNamee PT, Young IS, et al. (1995) Effect of hemodialysis on total antioxidant capacity and serum antioxidants in patients with chronic renal failure. Clin Chem 41(8 Pt 1): 1135–1138.
FIND THIS ARTICLE ONLINE - Cancer Therapy Evaluation Program, Common Terminology Criteria for Adverse Events, Version 3.0, DCTD, NCI, NIH, DHHS. March 31, 2003, Publish date: August 9, 2006
Available: http://ctep.cancer.gov/protocolDevelopment/ electronic_applications/docs/ ctcaev3.pdf - Eisenhauer EA, Therasse P, Bogaerts J, Schwartz LH, Sargent D, et al. (2009) New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1). Eur J Cancer 45(2): 228–247.
FIND THIS ARTICLE ONLINE - Shaib W, Deng Y, Zilterman D, Lundberg B, Saif MW (2010) Assessing risk and mortality of venous thromboembolism in pancreatic cancer patients. Anticancer Res 30(10): 4261–4264.
FIND THIS ARTICLE ONLINE - Feliu J, Borrega P, León A, López-Gómez L, López M, et al. (2011) Phase II study of a fixed dose-rate infusion of gemcitabine associated with erlotinib in advanced pancreatic cancer. Cancer Chemother Pharmacol 67(1): 215–221.
FIND THIS ARTICLE ONLINE - Cunningham D, Chau I, Stocken DD, Valle JW, Smith D, et al. (2009) Phase III randomized comparison of gemcitabine versus gemcitabine plus capecitabine in patients with advanced pancreatic cancer. J Clin Oncol 27(33): 5513–5518.
FIND THIS ARTICLE ONLINE - Ardavanis A, Kountourakis P, Karagiannis A, Doufexis D, Tzovaras AA, et al. (2009) Biweekly gemcitabine (GEM) in combination with erlotinib (ERL): an active and convenient regimen for advanced pancreatic cancer. Anticancer Res 29(12): 5211–5217.
FIND THIS ARTICLE ONLINE - Heinemann V, Quietzsch D, Gieseler F, Gonnermann M, Schönekäs H, et al. (2006) Randomized phase III trial of gemcitabine plus cisplatin compared with gemcitabine alone in advanced pancreatic cancer. J Clin Oncol 24: 3946–3952.
FIND THIS ARTICLE ONLINE - Stathopoulos GP, Syrigos K, Aravantinos G, Polyzos A, Papakotoulas P, et al. (2006) A multicenter phase III trial comparing irinotecan-gemcitabine (IG) with gemcitabine (G) monotherapy as first line treatment in patients with locally advanced or metastatic pancreatic cancer. Br J Cancer 95: 587–592.
FIND THIS ARTICLE ONLINE - Burris HA 3rd, Moore MJ, Andersen J, Green MR, Rothenberg ML, et al. (1997) Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: A randomized trial. J Clin Oncol 15: 2403–2413.
FIND THIS ARTICLE ONLINE - Drisko JA, Chapman J, Hunter VJ (2003) The use of antioxidants with first-line chemotherapy in two cases of ovarian cancer. J Amer Coll Nutr 22: 118–23.
FIND THIS ARTICLE ONLINE - Padayatty SJ, Riordan HD, Hewitt SM, Katz A, Hoffer LJ, et al. (2006) Intravenous vitamin C as cancer treatment: Three cases. Can Med Assoc J 174: 937–942.
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